Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.
Identifieur interne : 000389 ( Main/Exploration ); précédent : 000388; suivant : 000390Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.
Auteurs : Denisa Margin [Roumanie] ; Anca Ungurianu [Roumanie] ; Carmen Purdel [Roumanie] ; George Mihai Nitulescu [Roumanie] ; Dimitris Tsoukalas [Grèce] ; Evangelia Sarandi [Grèce] ; Maria Thanasoula [Grèce] ; Tatyana I. Burykina [Russie] ; Fotis Tekos [Grèce] ; Aleksandra Buha [Serbie] ; Dragana Nikitovic [Grèce] ; Demetrios Kouretas [Grèce] ; Aristidis Michael Tsatsakis [Russie]Source :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [ 1873-6351 ] ; 2020.
Abstract
Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments - redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.
DOI: 10.1016/j.fct.2020.111558
PubMed: 32640331
PubMed Central: PMC7335494
Affiliations:
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Burykina</name><affiliation wicri:level="3"><nlm:affiliation>Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tekos, Fotis" sort="Tekos, Fotis" uniqKey="Tekos F" first="Fotis" last="Tekos">Fotis Tekos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Buha, Aleksandra" sort="Buha, Aleksandra" uniqKey="Buha A" first="Aleksandra" last="Buha">Aleksandra Buha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, 11000, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, 11000, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Nikitovic, Dragana" sort="Nikitovic, Dragana" uniqKey="Nikitovic D" first="Dragana" last="Nikitovic">Dragana Nikitovic</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Histology-Embryology, Medical School, University of Crete, 71003, Heraklion, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Laboratory of Histology-Embryology, Medical School, University of Crete, 71003, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Kouretas, Demetrios" sort="Kouretas, Demetrios" uniqKey="Kouretas D" first="Demetrios" last="Kouretas">Demetrios Kouretas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Tsatsakis, Aristidis Michael" sort="Tsatsakis, Aristidis Michael" uniqKey="Tsatsakis A" first="Aristidis Michael" last="Tsatsakis">Aristidis Michael Tsatsakis</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia. 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Electronic address: anca.ungurianu@umfcd.ro.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Biochemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956</wicri:regionArea><wicri:noRegion>020956</wicri:noRegion></affiliation></author><author><name sortKey="Purdel, Carmen" sort="Purdel, Carmen" uniqKey="Purdel C" first="Carmen" last="Purdel">Carmen Purdel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Toxicology, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956</wicri:regionArea><wicri:noRegion>020956</wicri:noRegion></affiliation></author><author><name sortKey="Nitulescu, George Mihai" sort="Nitulescu, George Mihai" uniqKey="Nitulescu G" first="George Mihai" last="Nitulescu">George Mihai Nitulescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956</wicri:regionArea><wicri:noRegion>020956</wicri:noRegion></affiliation></author><author><name sortKey="Tsoukalas, Dimitris" sort="Tsoukalas, Dimitris" uniqKey="Tsoukalas D" first="Dimitris" last="Tsoukalas">Dimitris Tsoukalas</name><affiliation wicri:level="3"><nlm:affiliation>European Institute of Nutritional Medicine EINuM, Rome, Italy; Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>European Institute of Nutritional Medicine EINuM, Rome, Italy; Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Sarandi, Evangelia" sort="Sarandi, Evangelia" uniqKey="Sarandi E" first="Evangelia" last="Sarandi">Evangelia Sarandi</name><affiliation wicri:level="1"><nlm:affiliation>Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece; Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece; Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Thanasoula, Maria" sort="Thanasoula, Maria" uniqKey="Thanasoula M" first="Maria" last="Thanasoula">Maria Thanasoula</name><affiliation wicri:level="3"><nlm:affiliation>Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Burykina, Tatyana I" sort="Burykina, Tatyana I" uniqKey="Burykina T" first="Tatyana I" last="Burykina">Tatyana I. Burykina</name><affiliation wicri:level="3"><nlm:affiliation>Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tekos, Fotis" sort="Tekos, Fotis" uniqKey="Tekos F" first="Fotis" last="Tekos">Fotis Tekos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Buha, Aleksandra" sort="Buha, Aleksandra" uniqKey="Buha A" first="Aleksandra" last="Buha">Aleksandra Buha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, 11000, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, 11000, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Nikitovic, Dragana" sort="Nikitovic, Dragana" uniqKey="Nikitovic D" first="Dragana" last="Nikitovic">Dragana Nikitovic</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Histology-Embryology, Medical School, University of Crete, 71003, Heraklion, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Laboratory of Histology-Embryology, Medical School, University of Crete, 71003, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Kouretas, Demetrios" sort="Kouretas, Demetrios" uniqKey="Kouretas D" first="Demetrios" last="Kouretas">Demetrios Kouretas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Tsatsakis, Aristidis Michael" sort="Tsatsakis, Aristidis Michael" uniqKey="Tsatsakis A" first="Aristidis Michael" last="Tsatsakis">Aristidis Michael Tsatsakis</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia. Electronic address: tsatsaka@uoc.gr.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j">Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association</title><idno type="eISSN">1873-6351</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments - redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32640331</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6351</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>05</Day></PubDate></JournalIssue><Title>Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association</Title><ISOAbbreviation>Food Chem. Toxicol.</ISOAbbreviation></Journal><ArticleTitle>Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.</ArticleTitle><Pagination><MedlinePgn>111558</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0278-6915(20)30448-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fct.2020.111558</ELocationID><Abstract><AbstractText>Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments - redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Margină</LastName><ForeName>Denisa</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ungurianu</LastName><ForeName>Anca</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956, Romania. Electronic address: anca.ungurianu@umfcd.ro.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purdel</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Toxicology, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nitulescu</LastName><ForeName>George Mihai</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsoukalas</LastName><ForeName>Dimitris</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>European Institute of Nutritional Medicine EINuM, Rome, Italy; Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarandi</LastName><ForeName>Evangelia</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece; Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thanasoula</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Metabolomic Medicine Clinic, Health Clinics for Autoimmune and Chronic Diseases, 10674, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burykina</LastName><ForeName>Tatyana I</ForeName><Initials>TI</Initials><AffiliationInfo><Affiliation>Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tekos</LastName><ForeName>Fotis</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buha</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, 11000, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nikitovic</LastName><ForeName>Dragana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Laboratory of Histology-Embryology, Medical School, University of Crete, 71003, Heraklion, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kouretas</LastName><ForeName>Demetrios</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biochemistry-Biotechnology, School of Health Sciences, Larissa, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsatsakis</LastName><ForeName>Aristidis Michael</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia. Electronic address: tsatsaka@uoc.gr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Food Chem Toxicol</MedlineTA><NlmUniqueID>8207483</NlmUniqueID><ISSNLinking>0278-6915</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Inflammation</Keyword><Keyword MajorTopicYN="N">Nutraceuticals</Keyword><Keyword MajorTopicYN="N">Polyphenols</Keyword><Keyword MajorTopicYN="N">Polyunsaturated Fatty Acids</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32640331</ArticleId><ArticleId IdType="pii">S0278-6915(20)30448-8</ArticleId><ArticleId 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IdType="pubmed">28045400</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Grèce</li><li>Roumanie</li><li>Russie</li><li>Serbie</li></country><region><li>Attique (région)</li><li>District fédéral central</li></region><settlement><li>Athènes</li><li>Moscou</li></settlement></list><tree><country name="Roumanie"><noRegion><name sortKey="Margin, Denisa" sort="Margin, Denisa" uniqKey="Margin D" first="Denisa" last="Margin">Denisa Margin</name></noRegion><name sortKey="Nitulescu, George Mihai" sort="Nitulescu, George Mihai" uniqKey="Nitulescu G" first="George Mihai" last="Nitulescu">George Mihai Nitulescu</name><name sortKey="Purdel, Carmen" sort="Purdel, Carmen" uniqKey="Purdel C" first="Carmen" last="Purdel">Carmen Purdel</name><name sortKey="Ungurianu, Anca" sort="Ungurianu, Anca" uniqKey="Ungurianu A" first="Anca" last="Ungurianu">Anca Ungurianu</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Tsoukalas, Dimitris" sort="Tsoukalas, Dimitris" uniqKey="Tsoukalas D" first="Dimitris" last="Tsoukalas">Dimitris Tsoukalas</name></region><name sortKey="Kouretas, Demetrios" sort="Kouretas, Demetrios" uniqKey="Kouretas D" first="Demetrios" last="Kouretas">Demetrios Kouretas</name><name sortKey="Nikitovic, Dragana" sort="Nikitovic, Dragana" uniqKey="Nikitovic D" first="Dragana" last="Nikitovic">Dragana Nikitovic</name><name sortKey="Sarandi, Evangelia" sort="Sarandi, Evangelia" uniqKey="Sarandi E" first="Evangelia" last="Sarandi">Evangelia Sarandi</name><name sortKey="Tekos, Fotis" sort="Tekos, Fotis" uniqKey="Tekos F" first="Fotis" last="Tekos">Fotis Tekos</name><name sortKey="Thanasoula, Maria" sort="Thanasoula, Maria" uniqKey="Thanasoula M" first="Maria" last="Thanasoula">Maria Thanasoula</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Burykina, Tatyana I" sort="Burykina, Tatyana I" uniqKey="Burykina T" first="Tatyana I" last="Burykina">Tatyana I. Burykina</name></region><name sortKey="Tsatsakis, Aristidis Michael" sort="Tsatsakis, Aristidis Michael" uniqKey="Tsatsakis A" first="Aristidis Michael" last="Tsatsakis">Aristidis Michael Tsatsakis</name></country><country name="Serbie"><noRegion><name sortKey="Buha, Aleksandra" sort="Buha, Aleksandra" uniqKey="Buha A" first="Aleksandra" last="Buha">Aleksandra Buha</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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